A skin or soft tissue lesion procedure removes or treats an abnormal, bothersome, or suspicious area involving the skin or tissue beneath it. Depending on the lesion's size, location, and appearance, the physician may remove the entire area or take a smaller sample for testing. Local anesthesia is commonly used to numb the treatment area, and the incision may be closed with sutures when necessary. If tissue is removed, it may be sent to a pathology laboratory to determine exactly what the lesion is. Your care team will provide instructions for keeping the area clean, watching for signs of infection, and caring for the wound as it heals.